Ziya Kaya, MD and colleagues from Department of Internal Medicine III, Cardiology, University of Heidelberg, Germany took animal model experiment to study the effects on production of troponin-specific autoantibodies, cross-reactivity of autoantibodies, troponin-specific cellular response, inflammation, and expression of inflammatory cytokines, chemokines, fibrosis, heart function, ischemia/reperfusion injury, myocardial remodeling, and survival of the animals